L-759,633

Name: L-759,633
Brand: Tocris Bioscience
SKU: 2433

Cat. No. 2433 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2433 has been discontinued.

View all CB<sub>2</sub> Receptors products.

说明： High affinity, selective CB₂ agonist

化学名： (6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for L-759,633

High affinity, selective CB₂ receptor agonist (K_i values are 6.4 and 1043 nM for CB₂ and CB₁ receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB₂ receptors expressed in CHO cells (EC₅₀ = 8.1 nM).

技术数据 for L-759,633

分子量	384.59
公式	C₂₆H₄₀O₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	174627-50-0
PubChem ID	5311215
InChI Key	SUFMHSFGODDLKI-NHCUHLMSSA-N
Smiles	CCCCCCC(C)(C)C(C=C3OC)=CC2=[C@@]3[C@H]1[C@H]([C@@](C)(C)O2)CC=C(C)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for L-759,633

分析证书/产品说明书

化学品安全技术说明书

参考文献 for L-759,633

参考文献是支持产品生物活性的出版物。

Ross et al (1999) Agonist-inverse agonist characterization at CB₁ and CB₂ cannabinoid receptors of L759633, L759656 and AM630. Br.J.Pharmacol. 126 665 PMID: 10188977

Huffman et al (1999) 3-(1',1'-dimethylbutyl)-1-deoxy-D⁸-THC and related compounds: synthesis of selective ligands for the CB₂ receptor. Bioorg.Med.Chem. 7 2905 PMID: 10658595

Huffman (2000) The search for selective ligands for the CB₂ receptor. Curr.Pharmaceut.Des. 6 1323

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关键词: L-759,633, L-759,633 supplier, High, affinity, selective, CB2, agonists, cannabinoids, Receptors, cb2r, L759633, 2433, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.