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Submit ReviewL-759,656
说明： Highly selective CB2 agonist
化学名： (6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,8,9,10,10a-hexahydro-1-methoxy-6,6-dimethyl-9-methylene-6H-dibenzo[b,d]pyran
纯度： ≥98% (HPLC)
生物活性 for L-759,656
Highly selective CB2 receptor agonist (Ki values are 11.8 and 4888 nM for CB2 and CB1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 3.1 nM).
技术数据 for L-759,656
| 分子量 | 384.6 |
| 公式 | C26H40O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 174627-56-6 |
| PubChem ID | 5311216 |
| InChI Key | BJIIKHXAZBTGLF-NHCUHLMSSA-N |
| Smiles | C=C1C[C@@H]2[C@H]([C@@](C)(C)OC3=[C@]2C(OC)=CC(C(C)(C)CCCCCC)=C3)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for L-759,656
参考文献 for L-759,656
参考文献是支持产品生物活性的出版物。
Ross et al (1999) Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br.J.Pharmacol. 126 665 PMID: 10188977
Huffman (2005) CB2 receptor ligands. Mini Rev.Med.Chem. 5 641 PMID: 16026310
Huffman (2000) The search for selective ligands for the CB2 receptor. Curr.Pharmaceut.Des. 6 1323
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关键词: L-759,656, L-759,656 supplier, selective, CB2, agonists, cannabinoids, Receptors, cb2r, L759656, 2434, Tocris Bioscience
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该领域的文献
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.