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Submit ReviewL-AP5
说明： Potent and selective NMDA antagonist; less active form of DL-AP5
化学名： L-(+)-2-Amino-5-phosphonopentanoic acid
纯度： ≥99% (HPLC)
生物活性 for L-AP5
L-AP5 is an NMDA antagonist and an agonist at quisqualate-sensitized AP6 site, where it is more potent than the isomer D-AP5. L-AP5 is more potent than D-AP5 at depressing synaptic responses at amino acid-induced and synaptic excitation of cat spinal neurons.
D-isomer, DL mixture and sodium salt also available.
技术数据 for L-AP5
| 分子量 | 197.13 |
| 公式 | C5H12NO5P |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 79055-67-7 |
| PubChem ID | 1617110 |
| InChI Key | VOROEQBFPPIACJ-BYPYZUCNSA-N |
| Smiles | [H][C@@](CCCP(O)(O)=O)(N)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for L-AP5
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 100 |
制备储备液 for L-AP5
以下数据基于产品分子量 197.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.07 mL | 25.36 mL | 50.73 mL |
| 5 mM | 1.01 mL | 5.07 mL | 10.15 mL |
| 10 mM | 0.51 mL | 2.54 mL | 5.07 mL |
| 50 mM | 0.1 mL | 0.51 mL | 1.01 mL |
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产品说明书 for L-AP5
参考文献 for L-AP5
参考文献是支持产品生物活性的出版物。
Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378 PMID: 6145492
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024
Schulte et al (1994) Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203 PMID: 7953634
If you know of a relevant reference for L-AP5, please let us know.
按产品操作查看相关产品
关键词: L-AP5, L-AP5 supplier, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlu, Ionotropic, L-APV, LAPV, L_APV, LAP5, AP5, 0107, Tocris Bioscience
3 篇 L-AP5 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-AP5 的部分引用包括：
Fan et al (2016) Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice. Front Cell Neurosci 10 74 PMID: 27047338
Kinney (2005) GAT-3 transporters regulate inhibition in the neocortex. J Neurophysiol 94 4533 PMID: 16135550
Fernández-Monreal et al (2004) Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-MthD.-aspartate receptor signaling. J Biol Chem 279 50850 PMID: 15448144
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L-AP5 的评论
平均评分: 5 (Based on 1 Review.)
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AP5 decreases neuronal acitvity.
By
Luiz Alexandre Magno on 10/26/2018
分析类型： In Vivo
种属： Mouse
细胞系/组织： Brain
AP5 is an NMDA antagonist, so we have used it to block the function of neurons. Neuronal activity of animals injected with AP5 into the brain were decreased, seen as low expression of the protein CFOS.
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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