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Submit ReviewL-DOPA
说明： Dopamine precursor
别名： Levodopa
化学名： L-3,4-Dihydroxyphenylalanine
纯度： ≥98% (HPLC)
生物活性 for L-DOPA
L-DOPA is an immediate precursor of dopamine, produced by tyrosine hydroxylase. Displays antiParkinsonian activity.
技术数据 for L-DOPA
| 分子量 | 197.19 |
| 公式 | C9H11NO4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 59-92-7 |
| PubChem ID | 6047 |
| InChI Key | WTDRDQBEARUVNC-LURJTMIESA-N |
| Smiles | OC1=C(O)C=CC(C[C@H](N)C(O)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for L-DOPA
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 0.99 | 5 | |
| 1eq. HCl | 9.86 | 50 |
制备储备液 for L-DOPA
以下数据基于产品分子量 197.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 10.14 mL | 50.71 mL | 101.43 mL |
| 2.5 mM | 2.03 mL | 10.14 mL | 20.29 mL |
| 5 mM | 1.01 mL | 5.07 mL | 10.14 mL |
| 25 mM | 0.2 mL | 1.01 mL | 2.03 mL |
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产品说明书 for L-DOPA
参考文献 for L-DOPA
参考文献是支持产品生物活性的出版物。
Pisani and Shen (2009) Levodopa-induced dyskinesia and striatal signaling pathways. Proc.Natl.Acad.Sci.USA 106 2973
If you know of a relevant reference for L-DOPA, please let us know.
按标靶查看相关产品
关键词: L-DOPA, L-DOPA supplier, dopamine, precursor, non-selective, receptors, parkinson's, parkinsons, Levodopa, Non-selective, Dopamine, 3788, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Levodopa, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
5 篇 L-DOPA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-DOPA 的部分引用包括：
Christopher P et al (2021) Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Neuron 109 3421-3435.e5 PMID: 34506723
Alexander G et al (2021) Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum. Elife 10 PMID: 33983121
Marc et al (2021) Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways. Cell Rep 35 109136 PMID: 34010639
Xiao et al (2018) A Basal Ganglia Circuit Sufficient to Guide Birdsong Learning. Neuron 98 208 PMID: 29551492
Robert et al (2022) Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease. J Neuroinflammation 19 50 PMID: 35172843
您是否知道使用了 Tocris L-DOPA 的优秀论文？ 请告知我们.
L-DOPA 的评论
平均评分: 5 (Based on 1 Review.)
Have you used L-DOPA?
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Very stable compound.
By
Luiz Alexandre Magno on 10/26/2018
分析类型： In Vivo
种属： Mouse
I have used L-DOPA to increase dopamine in mouse brain. There was an increase in dopamine levels in the striatum of animals treated with 4 injections of L-DOPA.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.