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L-NAME hydrochloride

Cat. No. 0665 20 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Non-selective NOS inhibitor
化学名： NG-Nitro-L-arginine methyl ester hydrochloride
说明书
引用文献 (20)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for L-NAME hydrochloride

L-NAME hydrochloride is a NO synthase inhibitor.

化合物库 for L-NAME hydrochloride

L-NAME hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for L-NAME hydrochloride

分子量 269.69
公式 C7H15N5O4.HCl
储存 Store at RT
CAS Number 51298-62-5
PubChem ID 135193
InChI Key QBNXAGZYLSRPJK-JEDNCBNOSA-N
Smiles N=C(NCCC[C@H](N)C(OC)=O)N[N+]([O-])=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for L-NAME hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 26.97 100
DMSO 26.97 100

制备储备液 for L-NAME hydrochloride

以下数据基于产品分子量 269.69。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.54 mL 37.08 mL
5 mM 0.74 mL 3.71 mL 7.42 mL
10 mM 0.37 mL 1.85 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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产品说明书 for L-NAME hydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for L-NAME hydrochloride

参考文献是支持产品生物活性的出版物。

Knowles et al (1994) Nitric oxide synthases in mammals. Biochem.J. 298 249 PMID: 7510950

Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999

Pfeiffer et al (1996) Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, NG-nitro-L-arginine. Br.J.Pharmacol. 118 1433 PMID: 8832069

If you know of a relevant reference for L-NAME hydrochloride, please let us know.

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关键词: L-NAME hydrochloride, L-NAME hydrochloride supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Synthase, NO, Synthases, iNOS, eNOS, nNOS, Non-selective, 0665, Tocris Bioscience

20 篇 L-NAME hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 L-NAME hydrochloride 的部分引用包括：

Elks et al (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog 9 e1003789 PMID: 24367256

Lou et al (2009) Hydroxyurea generates nitric oxide in human erythroid cells: mechanisms for gamma-globin gene activation. Exp Biol Med (Maywood) 234 1374 PMID: 19657070

Casado et al (2000) Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Microbiol 97 11593 PMID: 11016958

Chen et al (2002) Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa J Virol 76 9407 PMID: 12186923

Townsend and Emala (2013) Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4. Am J Physiol Lung Cell Mol Physiol 305 L396 PMID: 23873842

Vaish and Singh (2013) Antioxidant Functions of Nitric Oxide Synthase in a Methicillin Sensitive Staphylococcus aureus. Br J Cancer 2013 312146 PMID: 23690783

Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830

Pearson et al (2009) Detection of EETs and HETE-generating cytochrome P-450 enzymes and the effects of their metabolites on myometrial and vascular function. Am J Physiol Endocrinol Metab 297 E647 PMID: 19549792

Safo and Regehr (2005) Endocannabinoids control the induction of cerebellar LTD. Neuron 48 647 PMID: 16301180

Cameron (2017) Structural and pharmacological basis for the induction of mitochondrial biogenesis by formo. but not clenbu. Sci Rep 7 10578 PMID: 28874749

Sunters et al (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i J Biol Chem 285 8743 PMID: 20042609

Silva et al (2007) Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro. Br J Pharmacol 151 195 PMID: 17375079

Gallo and Iadecola (2011) Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase. J Neurosci 31 6947 PMID: 21562256

Dai et al (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol 301 H1248 PMID: 21856924

Bucher et al (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037

Bice et al (2014) NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size. Cardiovasc Res 101 220 PMID: 24259501

Orru et al (2013) Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans. Neuropharmacology 67 476 PMID: 23261866

Gross et al (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol 59 20 PMID: 23419451

Gibson et al (2008) TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 57 746 PMID: 18341994

Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. Proc Natl Acad Sci U S A 35 5664 PMID: 25855180

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Effective nitric oxide synthase blocker.
By Karthik krishnamurthy on 10/26/2018
种属： Rat
细胞系/组织： astrocytes

Measured time lapse production of nitric oxide in astrocytes stimulated with 30 μM UTP with and without pretreatment with 100 μM L-NAME.

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