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Submit ReviewL-R4W2
说明： TRPV1 antagonist peptide
生物活性 for L-R4W2
L-R4W2 is a vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.
技术数据 for L-R4W2
| 分子量 | 1014.2 |
| 公式 | C46H71N21O6 |
| 序列 |
RRRRWW (Modifications: Trp-6 = C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 206350-79-0 |
| PubChem ID | 90479804 |
| InChI Key | MGQHBRDQUJRCLN-UJARKJSPSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for L-R4W2
参考文献 for L-R4W2
参考文献是支持产品生物活性的出版物。
Himmel et al (2002) The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons. J.Pharmacol.Exp.Ther. 301 981 PMID: 12023528
Planells-Cases et al (2000) Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 481 131 PMID: 10996311
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关键词: L-R4W2, L-R4W2 supplier, TRPV1, antagonists, peptide, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, 1577, Tocris Bioscience
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