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Lalistat 1

Cat. No. 6098 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective LAL inhibitor
化学名： 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Lalistat 1

Lalistat 1 is a potent and selective lysosomal acid lipase (LAL) inhibitor (IC50 = 68 nM). Exhibits no significant activity against pancreatic lipase or lipoprotein lipase at 10 μM concentration. Blocks LAL-mediated lipid hydrolysis of acetylated LDL and reduces efflux of cholesterol from lipid-loaded cells resulting in increased cellular cholesterol ester levels.

化合物库 for Lalistat 1

Lalistat 1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Lalistat 1

分子量 298.36
公式 C12H18N4O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 501104-16-1
PubChem ID 648404
InChI Key GKOPFXFKPASEFI-UHFFFAOYSA-N
Smiles O=C(OC1=NSN=C1N2CCCCC2)N3CCOCC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Lalistat 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.84 100
ethanol 29.84 100

制备储备液 for Lalistat 1

以下数据基于产品分子量 298.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.76 mL 33.52 mL
5 mM 0.67 mL 3.35 mL 6.7 mL
10 mM 0.34 mL 1.68 mL 3.35 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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参考文献 for Lalistat 1

参考文献是支持产品生物活性的出版物。

Rosenbaum et al (2009) Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim.Biophys.Acta. 1791 1155 PMID: 19699313

Ouimet et al (2011) Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 13 655 PMID: 21641547

Rosenbaum et al (2010) Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J.Med.Chem. 53 5281 PMID: 20557099

If you know of a relevant reference for Lalistat 1, please let us know.

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关键词: Lalistat 1, Lalistat 1 supplier, potent, selective, LAL, inhibitors, inhibits, lysosomal, acid, lipase, Neimann-Pick, type, c, NPC, storage, cholesterol, accumulation, Lalistat1, Lysosomal, Acid, Lipase, (LAL), 6098, Tocris Bioscience

3 篇 Lalistat 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Lalistat 1 的部分引用包括：

Shaun G et al (2019) Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes. J Cell Biol 218 3320-3335 PMID: 31391210

Mariam et al (2021) Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis. Autophagy 17 690-705 PMID: 32070194

Wu et al (2019) Evidence for a Novel Regulatory Interaction Involving Cyclin D1, Lipid Droplets, Lipolysis, and Cell Cycle Progression in Hepatocytes. Hepatol Commun 3 406 PMID: 30859152

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