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Lalistat 2

Cat. No. 6099 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective LAL inhibitor
化学名： 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Lalistat 2

Lalistat 2 is a selective lysosomal acid lipase inhibitor (IC50 = 152 nM). Exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).

化合物库 for Lalistat 2

Lalistat 2 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Lalistat 2

分子量 296.39
公式 C13H20N4O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1234569-09-5
PubChem ID 46867138
InChI Key PNYYVHOTXOEBEV-UHFFFAOYSA-N
Smiles O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Lalistat 2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.64 100
ethanol 29.64 100

制备储备液 for Lalistat 2

以下数据基于产品分子量 296.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.74 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Lalistat 2

参考文献是支持产品生物活性的出版物。

Rosenbaum et al (2009) Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim.Biophys.Acta. 1791 1155 PMID: 19699313

Hamilton et al (2012) A new method for the measurement of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2. Clin.Chim.Acta. 413 1207 PMID: 22483793

Rosenbaum et al (2010) Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J.Med.Chem. 53 5281 PMID: 20557099

If you know of a relevant reference for Lalistat 2, please let us know.

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关键词: Lalistat 2, Lalistat 2 supplier, Lalistat2, selective, lysosomal, acid, lipase, inhibitors, inhibits, Niemann-Pick, type, C, (NPC), disease, is, a, storage, disorder, Lysosomal, Acid, Lipase, (LAL), 6099, Tocris Bioscience

2 篇 Lalistat 2 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Lalistat 2 的部分引用包括：

Debaditya et al (2020) Serum lipoprotein-derived fatty acids regulate hypoxia-inducible factor. J Biol Chem 295 18284-18300 PMID: 33109611

Debaditya et al (2020) Serum lipoprotein-derived fatty acids regulate hypoxia-inducible factor. J Biol Chem 295 18284-18300 PMID: 33453834

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