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Submit ReviewLamotrigine
说明： Inhibits glutamate release. Anticonvulsant
化学名： 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
纯度： ≥99% (HPLC)
生物活性 for Lamotrigine
Lamotrigine is an anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na+ channels.
Water-soluble Salt also available.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
技术数据 for Lamotrigine
| 分子量 | 256.09 |
| 公式 | C9H7Cl2N5 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 84057-84-1 |
| PubChem ID | 3878 |
| InChI Key | PYZRQGJRPPTADH-UHFFFAOYSA-N |
| Smiles | NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Lamotrigine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 25.61 | 100 |
制备储备液 for Lamotrigine
以下数据基于产品分子量 256.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.9 mL | 19.52 mL | 39.05 mL |
| 5 mM | 0.78 mL | 3.9 mL | 7.81 mL |
| 10 mM | 0.39 mL | 1.95 mL | 3.9 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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产品说明书 for Lamotrigine
参考文献 for Lamotrigine
参考文献是支持产品生物活性的出版物。
Grunze et al (1998) Modulation of calcium and potassium currents by lamotr. Neuropsychobiology 38 131 PMID: 9778600
Leach et al (1991) Neurochemical and behavioral aspects of lamotr. Epilepsia 32 S4 PMID: 1685439
Zheng et al (2010) The anticonvulsive drug lamotr. blocks neuronal α4β2 nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 335 401 PMID: 20688974
Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522 PMID: 9184596
If you know of a relevant reference for Lamotrigine, please let us know.
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关键词: Lamotrigine, Lamotrigine supplier, inhibitors, glutamate, release, Anticonvulsant, Blocks, Na+, K+, Ca2+, calcium, sodium, potassium, channels, inhibits, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, Channel, modulators, VDAC, GlaxoSmithKline, GSK, Miscellaneous, Other, Modulators, 1611, Tocris Bioscience
2 篇 Lamotrigine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Lamotrigine 的部分引用包括：
Lazar et al (2015) Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway. Front Pharmacol 6 210 PMID: 26441665
Kashyap et al (2015) Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation. J Neurosci 2 PMID: 26709376
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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