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Submit ReviewLatrunculin A
说明： Inhibitor of actin assembly and polymerization
化学名： 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
纯度： ≥95% (HPLC)
生物活性 for Latrunculin A
Latrunculin A is a reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.
This product is typically reconstituted in DMSO as a primary solvent.
技术数据 for Latrunculin A
| 分子量 | 421.55 |
| 公式 | C22H31NO5S |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 76343-93-6 |
| PubChem ID | 445420 |
| InChI Key | DDVBPZROPPMBLW-IZGXTMSKSA-N |
| Smiles | C[C@@H](CC[C@]2([H])C[C@@](C[C@](O)([C@]3([H])CSC(N3)=O)O2)([H])O1)\C=C/C=C/CC/C(C)=C\C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Latrunculin A
参考文献 for Latrunculin A
参考文献是支持产品生物活性的出版物。
Yarmola et al (2000) Actin-latrunculin A structure and function. J.Biol.Chem. 275 28120 PMID: 10859320
Morton et al (2000) Latrunculin alters the actin-monomer subunit interface to prevent polymerization. Nat.Cell Biol. 2 376 PMID: 10854330
Blasberger et al (1989) On the chemistry of latrunculins A and B. Liebigs.Ann.Chem. 1989 1171
If you know of a relevant reference for Latrunculin A, please let us know.
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关键词: Latrunculin A, Latrunculin A supplier, inhibits, inhibitors, actin, assembly, polymerization, polymerisation, LatrunculinA, Actin, 3973, Tocris Bioscience
32 篇 Latrunculin A 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Latrunculin A 的部分引用包括：
Zheng et al (2019) A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport. Cell Rep 28 3224-3237.e5 PMID: 31533043
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Lettau et al (2018) Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells. Int Immunol 30 215 PMID: 29373679
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