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Submit ReviewLazabemide hydrochloride
说明： Selective MAO-B inhibitor
别名： Ro 19-6327
化学名： N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Lazabemide hydrochloride
Lazabemide hydrochloride is a selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC50 values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively).
技术数据 for Lazabemide hydrochloride
| 分子量 | 236.1 |
| 公式 | C8H10ClN3O.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 103878-83-7 |
| PubChem ID | 163727 |
| InChI Key | JMFKTFLARGGXCC-UHFFFAOYSA-N |
| Smiles | Cl.NCCNC(=O)C1=NC=C(Cl)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Lazabemide hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 23.61 | 100 | |
| DMSO | 23.61 | 100 |
制备储备液 for Lazabemide hydrochloride
以下数据基于产品分子量 236.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.24 mL | 21.18 mL | 42.35 mL |
| 5 mM | 0.85 mL | 4.24 mL | 8.47 mL |
| 10 mM | 0.42 mL | 2.12 mL | 4.24 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.85 mL |
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产品说明书 for Lazabemide hydrochloride
参考文献 for Lazabemide hydrochloride
参考文献是支持产品生物活性的出版物。
Saura et al (1992) Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J.Neurosci. 12 1977 PMID: 1578281
Bondiolotti et al (1995) In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl. Biochem.Pharmacol. 50 97 PMID: 7605351
Guimaraes and Soares-da-Silva (1998) The activity of MAO A and B in rat renal cells and tubules. Life Sci. 62 727 PMID: 9489509
If you know of a relevant reference for Lazabemide hydrochloride, please let us know.
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关键词: Lazabemide hydrochloride, Lazabemide hydrochloride supplier, Selective, MAO-B, inhibitors, inhibits, Monoamine, Oxygenases, Oxidases, Ro196327, Ro, 19-6327, Oxidase, Adrenergic, Related, Compounds, Dopaminergic-Related, 5-HT-Related, 5-HT3, Receptors, 2460, Tocris Bioscience
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