LEI 101 hydrochloride

Cat. No. 5826 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective CB₂ partial agonist; orally biovailable

化学名： 3-Cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-2,4-imidazolidinedione hydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for LEI 101 hydrochloride

LEI 101 hydrochloride is a potent and selective CB₂ partial agonist (pEC₅₀ = 8.0). Exhibits >100-fold selectivity for CB₂ over CB₁ and no significant interaction with hFAAH, MAGL, DAGL or NAPE-PLD. Displays antinociceptive activity in a rat neuropathic pain model and attenuates renal inflammation in a mouse kidney damage model. Orally bioavailable with low brain penetration.

技术数据 for LEI 101 hydrochloride

分子量	508.99
公式	C₂₃H₂₅FN₄O₄S.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2250025-91-1
PubChem ID	127021038
InChI Key	APLLNJWPLUIBCG-UHFFFAOYSA-N
Smiles	FC1=CC=C(C2=CC=C(C=C2)CN3CC(N(C3=O)C4CC4)=O)N=C1CN5CCS(=O)(CC5)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LEI 101 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	50.9	100

制备储备液 for LEI 101 hydrochloride

以下数据基于产品分子量 508.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.96 mL	9.82 mL	19.65 mL
5 mM	0.39 mL	1.96 mL	3.93 mL
10 mM	0.2 mL	0.98 mL	1.96 mL
50 mM	0.04 mL	0.2 mL	0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for LEI 101 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for LEI 101 hydrochloride

参考文献是支持产品生物活性的出版物。

van der Stelt M et al (2011) Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB₂ receptor agonists. J.Med.Chem. 54 7350 PMID: 21923175

Mukhopadhyay et al (2016) The novel, orally available and peripherally restricted selective cannabinoid CB₂ receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. Br.J.Pharmacol. 173 446 PMID: 26398481

If you know of a relevant reference for LEI 101 hydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 CB₂ Receptor Agonists

关键词: LEI 101 hydrochloride, LEI 101 hydrochloride supplier, LEI101, hydrochloride, cannabinoid, CB2, partial, agonists, potent, selective, agonism, orally, bioavailable, anti-inflammatory, Receptors, 5826, Tocris Bioscience

篇 LEI 101 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 LEI 101 hydrochloride 的引用文献。您是否知道使用了 Tocris LEI 101 hydrochloride 的优秀论文？请告知我们.