主页 / 药理学 / Enzymes / Esterases / Phospholipases / Phospholipase Inhibitors / LEI 401

LEI 401

Cat. No. 7407 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor
化学名： N-(Cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]-4-pyrimidinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LEI 401

LEI 401 is a high affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor (Ki = 0.027 and 0.18 μM for human and mouse NAPE-PLD, respectively; IC50 for human enzyme = 0.86 μM). LEI 401 exhibits no significant activity at cannabinoid receptors or other metabolic enzymes of the endocannabinoid system. The product reduces levels of N-acylethanolamines (NAE) in a neuroblastoma cell line in vitro. It also reduces anandamide levels in mouse brain in vivo and impairs fear extinction. LEI 701 is CNS penetrant and cell-permeable.

许可信息

Sold with kind permission of Professor van der Stelt

化合物库 for LEI 401

LEI 401 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for LEI 401

分子量 421.55
公式 C24H31N5O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2393840-15-6
PubChem ID 145998143
InChI Key GFHJYPQZBBHOCC-UXHICEINSA-N
Smiles O[C@H]1CCN(C2=NC(N3CCC[C@@H](C4=CC=CC=C4)C3)=NC(C(NCC5CC5)=O)=C2)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LEI 401

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.16 100
ethanol 21.1 50

制备储备液 for LEI 401

以下数据基于产品分子量 421.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.86 mL 23.72 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.19 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for LEI 401

参考文献是支持产品生物活性的出版物。

Mock et al (2020) Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nat.Chem.Biol. 16 667 PMID: 32393901

If you know of a relevant reference for LEI 401, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Phospholipase Inhibitors

关键词: LEI 401, LEI 401 supplier, LEI401, N-acylphosphatidylethanolamine, phospholipase, D, NAPEPLD, N-acylethanolamines, NAE, inhibitors, inhibits, high, affinity, brain, penetrant, cell, permeable, endocannabinoids, cannabinoids, Phospholipases, 7407, Tocris Bioscience

篇 LEI 401 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 LEI 401 的引用文献。 您是否知道使用了 Tocris LEI 401 的优秀论文？ 请告知我们.

LEI 401 的评论

目前没有该产品的评论。 Be the first to review LEI 401 and earn rewards!

Have you used LEI 401?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review