Lercanidipine hydrochloride

Name: Lercanidipine hydrochloride
Brand: Tocris Bioscience
SKU: 2959
Rating: 5 (1 reviews)

Cat. No. 2959 1 次引用 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2959 has been discontinued.

View all Ca<sub>V</sub>1.x Channels (L-type) products.

说明： Ca_V1.x blocker

化学名： 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Lercanidipine hydrochloride

Lercanidipine hydrochloride is a L-type Ca²⁺ channel blocker that displays higher vascular selectivity than felodipine (Cat. No. 2960). Causes peripheral vasodilation with only weak negative inotropic activity. Antihypertensive. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC₅₀ = 2.36 μM).

技术数据 for Lercanidipine hydrochloride

分子量	648.19
公式	C₃₆H₄₁N₃O₆.HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	132866-11-6
PubChem ID	157917
InChI Key	WMFYOYKPJLRMJI-UHFFFAOYSA-N
Smiles	CC1=C(C(OC(C)(C)CN(C)CCC(C4=CC=CC=C4)C3=CC=CC=C3)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C(C(OC)=O)=C(C)N1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Lercanidipine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Lercanidipine hydrochloride

参考文献是支持产品生物活性的出版物。

Bang et al (2003) Lercanidipine. A review of its efficacy in the management of hypertension. Drugs 63 2449 PMID: 14609358

Wirtz and Herzig (2004) Molecular mechanisms of vasoselectivity of the 1,4-dihydropyridine lercanidipine. Br.J.Pharmacol. 142 275 PMID: 15155536

Sironi et al (1996) Antihypertensive effects of lercanidipine in experimental hypertensive rats and dogs. Arzneim.Forsch. 46 152

Ko et al (2021) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 13 PMID: 33918958

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关键词: Lercanidipine hydrochloride, Lercanidipine hydrochloride supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, COVID-19, MERS-CoV, middle, eastern, respiratory, syndrome, Cav1.x, Coronavirus, 2959, Tocris Bioscience

1 篇 Lercanidipine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Lercanidipine hydrochloride 的部分引用包括：

Vasigar (2013) Anti-inflammatoryactivity of calciumchannel blocker lercanidipine hydrochloride. J Pharmacol Pharmacother 4 238 PMID: 24250199