Letrozole

Cat. No. 4382 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, reversible non-steroidal aromatase inhibitor

别名： CGS 20267

化学名： 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile

纯度： ≥99% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Letrozole

Letrozole is a potent, reversible non-steroidal aromatase inhibitor (IC₅₀ = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells.

化合物库 for Letrozole

Letrozole is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Letrozole

分子量	285.3
公式	C₁₇H₁₁N₅
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	112809-51-5
PubChem ID	3902
InChI Key	HPJKCIUCZWXJDR-UHFFFAOYSA-N
Smiles	N#CC(C=C2)=CC=C2C(N3N=CN=C3)C1=CC=C(C#N)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Letrozole

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	28.53	100

制备储备液 for Letrozole

以下数据基于产品分子量 285.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.51 mL	17.53 mL	35.05 mL
5 mM	0.7 mL	3.51 mL	7.01 mL
10 mM	0.35 mL	1.75 mL	3.51 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

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产品说明书 for Letrozole

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Letrozole

参考文献是支持产品生物活性的出版物。

Mitropoulou et al (2003) Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells. Int.J.Cancer 104 155 PMID: 12569569

Bhatnagar et al (1990) Highly selective inhbition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 37 1021 PMID: 2149502

Bhatnagar (2007) The discovery and mechanism of action of letr. Breast Cancer Res.Treat. 105 7 PMID: 17912633

If you know of a relevant reference for Letrozole, please let us know.

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