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Levetiracetam

Cat. No. 2839 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Binds SV2A; antiepileptic
别名： Keppra,UCB L059
化学名： (2S)-(2-Oxopyrrolidin-1-yl)butyramide
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Levetiracetam

Levetiracetam is an antiepileptic that displays distinctive properties from conventional antiepileptic drugs. Displays potent seizure protection in animal models of chronic epilepsy but lacks activity in acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na+-dependent Cl-/HCO3- exchange. In a mouse model of Alzheimer's disease, Levetiracetam rescues levels of presynaptic vesicle fusion and neurotransmitter release, reduces Aβ42 and APP levels and decreases deposits of amyloid plaque; in vitro Levetiracetam inhibits Aβ-induced glutamate from astrocytes.

化合物库 for Levetiracetam

Levetiracetam is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Levetiracetam

分子量 170.21
公式 C8H14N2O2
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 102767-28-2
PubChem ID 5284583
InChI Key HPHUVLMMVZITSG-LURJTMIESA-N
Smiles O=C1N([C@@H](CC)C(N)=O)CCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Levetiracetam

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 17.02 100
DMSO 17.02 100

制备储备液 for Levetiracetam

以下数据基于产品分子量 170.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 5.88 mL 29.38 mL 58.75 mL
5 mM 1.18 mL 5.88 mL 11.75 mL
10 mM 0.59 mL 2.94 mL 5.88 mL
50 mM 0.12 mL 0.59 mL 1.18 mL

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产品说明书 for Levetiracetam

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Levetiracetam

参考文献是支持产品生物活性的出版物。

Smedt et al (2007) LeveT: the profile of a novel anticonvulsant drug - part I: preclinical data. CNS Drug Rev. 13 43 PMID: 17461889

Ueda et al (2007) Effect of LeveT on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection. Brain Res. 1151 55 PMID: 17408599

Lynch et al (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug LeveT. Proct.Natl.Acad.Sci. USA 101 9861 PMID: 15210974

Sanchez et al (2012) Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc.Natl.Acad.Sci. USA 109 E2895 PMID: 22869752

Sanz-Blasco et al (2016) Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes. Neuroreport 27 705 PMID: 27183239

Rao and Savas (2021) Levetiracetam treatment normalizes levels of presynaptic endocytosis machinery and restores nonamyloidogenic APP processing in App knock-in mice J.Proteome Res. 20 3580 PMID: 34106705

If you know of a relevant reference for Levetiracetam, please let us know.

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关键词: Levetiracetam, Levetiracetam supplier, Anti-epileptic, binds, SV2A, Exocytosis, Endocytosis, Protein, Translocation, UCBL059, Alzheimers, APP, amyloid, precursor, protein, Ab, Abeta, Aβ, Keppra, UCB, L059, 2839, Tocris Bioscience

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