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Submit ReviewLG 100754
说明： RXR:PPAR agonist
化学名： (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoic acid
纯度： ≥99% (HPLC)
生物活性 for LG 100754
Novel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARα heterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Exhibits antidiabetic properties in vivo.
技术数据 for LG 100754
| 分子量 | 396.56 |
| 公式 | C26H36O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 180713-37-5 |
| PubChem ID | 6442223 |
| InChI Key | HNODNXQAYXJFMQ-LQUSFLDPSA-N |
| Smiles | CC1(C)C2=C(C=C(OCCC)C(/C(C)=C\C=C\C(C)=C\C(O)=O)=C2)C(C)(C)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LG 100754
参考文献 for LG 100754
参考文献是支持产品生物活性的出版物。
Cesario et al (2001) The retinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo. Mol.Endocrinol. 15 1360 PMID: 11463859
Forman (2002) The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor γ ligands. J.Biol.Chem. 277 12503 PMID: 11877384
Germain et al (2006) International union of pharmacology LXIII. Retinoid X receptors. Pharmacol.Rev. 58 760 PMID: 17132853
Sato et al (2010) The "Phantom Effect" of the rexinoid LG100754: structural and functional insights. PLoS One 5 e15119 PMID: 21152046
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关键词: LG 100754, LG 100754 supplier, LG100754, selective, retinoid, x, receptors, RXR, nuclear, ppar, peroxisome, proliferator, activated, PPARgamma, PPARg, PPARγ, agonists, sensitizers, Retinoid, X, Receptor, Receptors, 3831, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.