Liarozole dihydrochloride

Cat. No. 2705 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Blocks retinoic acid metabolism

别名： R-75251

化学名： 5-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazole dihydrochloride

纯度： ≥99% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Liarozole dihydrochloride

Liarozole dihydrochloride is a cytochrome P450 inhibitor. Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Blocks retinoic acid metabolism (retinoic acid metabolism blocking agent, RAMBA). Displays antitumor activity against androgen-dependent and independent rat prostate carcinomas.

化合物库 for Liarozole dihydrochloride

Liarozole dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Liarozole dihydrochloride

分子量	381.69
公式	C₁₇H₁₃ClN₄.2HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	1883548-96-6
PubChem ID	121513844
InChI Key	NKDMRTVUEJWCCQ-UHFFFAOYSA-N
Smiles	ClC1=CC(C(N4C=CN=C4)C2=CC=C(N=CN3)C3=C2)=CC=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Liarozole dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	38.17	100
	water	34.52	100

制备储备液 for Liarozole dihydrochloride

以下数据基于产品分子量 381.69。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.1 mL	26.2 mL
5 mM	0.52 mL	2.62 mL	5.24 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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产品说明书 for Liarozole dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Liarozole dihydrochloride

参考文献是支持产品生物活性的出版物。

Van Wauwe et al (1992) Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. J.Pharmacol.Exp.Ther. 261 773 PMID: 1374473

Njar et al (2006) Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases. Bioorg.Med.Chem. 14 4323 PMID: 16530416

Goss et al (2007) Effects of liarozole fumarate (R85246) in combination with tamox. on N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma and uterus in the rat model. BMC Cancer 7 26 PMID: 17266767

If you know of a relevant reference for Liarozole dihydrochloride, please let us know.

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关键词: Liarozole dihydrochloride, Liarozole dihydrochloride supplier, Cytochrome, P450, CYP26, inhibitors, inhibits, blocks, retinoic, acid, metabolism, Blocks, RXR, Retinoid, X, Receptors, CYP, RAR, RAMBA, Retinoic, Acid, R75251, R-75251, Receptor, 2705, Tocris Bioscience

3 篇 Liarozole dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Liarozole dihydrochloride 的部分引用包括：

Bunt et al (2016) Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model. Islets 8 83 PMID: 27246810

Bhattacharya et al (2016) Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer Immunity 45 1 PMID: 27590114

Thomas and Henry (2014) Retinoic acid regulation by CYP26 in vertebrate lens regeneration. Neuropsychopharmacology 386 291 PMID: 24384390

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