主页 / 药理学 / Enzyme-Linked Receptors / Receptor Tyrosine Kinases (RTKs) / PDGFR / PDGFR Inhibitors / Linifanib

Linifanib

Cat. No. 7743 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R
化学名： N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Linifanib

Linifanib is a potent receptor tyrosine kinase (RTK) inhibitor. It inhibits PDGFRβ, KDR, FLT3, CSF-1R (IC50 values are 2, 4, 4 and 7 nM, respectively). Linifanib inhibits angiogenesis in vascularized micro-organs and potently inhibits VEGF-stimulated endothelial cell proliferation (IC50 = 0.2 nM). Linifanib also promotes the generation and reprogramming of iPSCs from somatic cells.

技术数据 for Linifanib

分子量 375.4
公式 C21H18FN5O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 796967-16-3
PubChem ID 11485656
InChI Key MPVGZUGXCQEXTM-UHFFFAOYSA-N
Smiles O=C(NC=1C=CC(=CC1)C=2C=CC=C3NN=C(N)C32)NC4=CC(=CC=C4F)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Linifanib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 7.51 20
DMSO 37.54 100

制备储备液 for Linifanib

以下数据基于产品分子量 375.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.32 mL 26.64 mL
5 mM 0.53 mL 2.66 mL 5.33 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Linifanib

参考文献是支持产品生物活性的出版物。

Albert et al (2006) Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol.Cancer Ther. 5 995 PMID: 16648571

Guan et al (2022) Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605 325 PMID: 35418683

Jahid et al (2022) Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 39 110641 PMID: 35385746

If you know of a relevant reference for Linifanib, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 PDGFR Inhibitors

关键词: Linifanib, Linifanib supplier, receptor, tyrosine, kinases, inhibitors, potent, vegfr, pdgfr, angiogeneis, stem, cells, reprogramming, iPSC, PDGFR, VEGFR, Stem, Cell, Reprogramming, 7743, Tocris Bioscience

篇 Linifanib 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Linifanib 的引用文献。 您是否知道使用了 Tocris Linifanib 的优秀论文？ 请告知我们.

Linifanib 的评论

目前没有该产品的评论。 Be the first to review Linifanib and earn rewards!

Have you used Linifanib?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.