Liproxstatin-1 hydrochloride

Cat. No. 6113 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent ferroptosis inhibitor

化学名： N-[(3-Chlorophenyl)methyl]spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine hydrochloride

纯度： ≥98% (HPLC)

文献 (3)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Liproxstatin-1 hydrochloride

Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor (IC₅₀ = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.

化合物库 for Liproxstatin-1 hydrochloride

Liproxstatin-1 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Liproxstatin-1 hydrochloride

分子量	377.31
公式	C₁₉H₂₁ClN₄.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2250025-95-5
PubChem ID	134160236
InChI Key	HEHOHTKMIOBTKC-UHFFFAOYSA-N
Smiles	C1CNCCC12C(=NC3=CC=CC=C3N2)NCC4=CC(=CC=C4)Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Liproxstatin-1 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	37.73	100

制备储备液 for Liproxstatin-1 hydrochloride

以下数据基于产品分子量 377.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.25 mL	26.5 mL
5 mM	0.53 mL	2.65 mL	5.3 mL
10 mM	0.27 mL	1.33 mL	2.65 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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产品说明书 for Liproxstatin-1 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Liproxstatin-1 hydrochloride

参考文献是支持产品生物活性的出版物。

Friedmann Angeli et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat.Cell.Biol. 16 1180 PMID: 25402683

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关键词: Liproxstatin-1 hydrochloride, Liproxstatin-1 hydrochloride supplier, 950455-15-9, ferroptosis, inhibitor, inhibits, potent, GPX4, Ferroptosis, 6113, Tocris Bioscience

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