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Lisuride maleate

Cat. No. 4052 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Dopamine agonist; antiparkinson's agent
化学名： N'-[(8α)-9,10-Didehydro-6-methylergolin-8-yl]-N,N-diethylurea maleate
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Lisuride maleate

Lisuride maleate is a dopamine receptor agonist and anti-Parkinson's agent. Displays high affinity for D2, D3 and D4 receptors along with 5-HT1A. Exhibits some 5-HT2B receptor antagonist properties. Decreases prolactin release; reduces inflammatory mediators such as TNF-α and IL6. Exhibits anticonvulsive effects. Acts similar to bromocriptine (Cat. No. 0427).

技术数据 for Lisuride maleate

分子量 454.52
公式 C20H26N4O.C4H4O4
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 19875-60-6
PubChem ID 5282421
InChI Key CVQFAMQDTWVJSV-BAXNFHPCSA-N
Smiles OC(/C=C\C(O)=O)=O.[H][C@@]1(C2)C(C3=C4C2=CNC4=CC=C3)=C[C@H](NC(N(CC)CC)=O)CN1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Lisuride maleate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.66 100

制备储备液 for Lisuride maleate

以下数据基于产品分子量 454.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.2 mL 11 mL 22 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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产品说明书 for Lisuride maleate

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Lisuride maleate

参考文献是支持产品生物活性的出版物。

Hofmann et al (2006) Lisuride, a DA receptor agonist with 5-HT2B receptor antagonist properties: absence of cardiac valvulopathy adverse drug reaction reports supports the concept of a crucial role for 5-HT2B receptor agonism in cardiac valvular fibrosis Clin.Neuropharmacol. 29 80 PMID: 16614540

Zweckberger et al (2010) Anticonvulsive effects of the DA agonist lisuride maleate after experimental traumatic brain injury. Neurosci.Lett. 470 150 PMID: 20056133

Woitalla et al (2004) Transdermal lisuride delivery in the treatment of Parkinson's disease. J.Neural Transm. 68 89

If you know of a relevant reference for Lisuride maleate, please let us know.

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关键词: Lisuride maleate, Lisuride maleate supplier, antiparkinsonian, drug, anti-Parkinson's, disease, dopaminergic, agonists, dopamine, receptor, agonist, DA, Non-selective, Dopamine, 5-HT, 4052, Tocris Bioscience

4 篇 Lisuride maleate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Lisuride maleate 的部分引用包括：

Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264

Chan et al (2018) Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy. Elife 7 PMID: 30059006

McCorvy et al (2018) Structural determinants of 5-HT2B receptor activation and biased agonism. Nat Struct Mol Biol 25 787 PMID: 30127358

Tomasz et al (2023) Psychedelics promote plasticity by directly binding to BDNF receptor TrkB. Nat Neurosci 26 1032-1041 PMID: 37280397

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.