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Submit ReviewLM11A 31 dihydrochloride
说明： Nonpeptide p75NTR ligand; neuroprotective
化学名： (2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride
纯度： ≥95% (HPLC)
生物活性 for LM11A 31 dihydrochloride
LM11A 31 dihydrochloride is a nonpeptide p75NTR ligand and nerve growth factor (NGF) antagonist. LM11A 31 blocks p75-mediated cell death, inhibits proNGF induced cell death (IC50 = 1-10 nM), increases proliferation and survival of hippocampal neural progenitors and inhibits Aβ-induced cell death (EC50 = 20 nM). In animal models of Alzheimer's disease LM11A 31 prevents and reverses atrophy of cholinergic neurites and reverses Alzheimer's pathology; in models of Huntington's disease LM11A 31 increases survival, reduces the formation of aggregates of mutant huntingtin and neuronal degeneration. Also promotes functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.
技术数据 for LM11A 31 dihydrochloride
| 分子量 | 316.27 |
| 公式 | C12H25N3O2.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1243259-19-9 |
| PubChem ID | 91654620 |
| InChI Key | LLIHJRRZJDEKLB-ULEGLUPFSA-N |
| Smiles | O=C([C@@H](N)[C@@H](C)CC)NCCN1CCOCC1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LM11A 31 dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 31.63 | 100 | |
| DMSO | 31.63 | 100 |
制备储备液 for LM11A 31 dihydrochloride
以下数据基于产品分子量 316.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.16 mL | 15.81 mL | 31.62 mL |
| 5 mM | 0.63 mL | 3.16 mL | 6.32 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.16 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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产品说明书 for LM11A 31 dihydrochloride
参考文献 for LM11A 31 dihydrochloride
参考文献是支持产品生物活性的出版物。
Shi et al (2013) A small molecule P75NTR ligand protects neurogenesis after traumatic brain injury. Stem Cells [Epub ahead of print] PMID: 23940017
Massa et al (2006) Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. J.Neurosci. 26 5288 PMID: 6707781
Tep et al (2013) Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury. J.Neurosci. 33 397 PMID: 23303920
Simmons et al (2014) A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One 9 e102136 PMID: 25153701
Simmons et al (2016) A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Hum.Mol.Genet. 25 4920 PMID: 28171570
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关键词: LM11A 31 dihydrochloride, LM11A 31 dihydrochloride supplier, LM11A31, dihydrochloride, p75NTR, ligands, selective, NGFR, nerve, growth, factor, receptors, Alzheimer's, Disease, neuroprotective, Trk, Receptors, Neuronal, Metabolism, 5046, Tocris Bioscience
1 篇 LM11A 31 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LM11A 31 dihydrochloride 的部分引用包括：
H Uri et al (2017) p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa. Cell Death Dis 8 e2922 PMID: 28703796
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.