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LNT 1

Cat. No. 6510 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
化学名： 1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LNT 1

LNT 1 is a potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.

化合物库 for LNT 1

LNT 1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for LNT 1

分子量 332.33
公式 C15H12N2O5S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 824983-91-7
PubChem ID 11652865
InChI Key MXQGCMQXTPTJJT-UHFFFAOYSA-N
Smiles ON1C(N(C2=C(C1=O)SC=C2)CC3COC4=CC=CC=C4O3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LNT 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 16.62 50

制备储备液 for LNT 1

以下数据基于产品分子量 332.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 6.02 mL 30.09 mL 60.18 mL
2.5 mM 1.2 mL 6.02 mL 12.04 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
25 mM 0.12 mL 0.6 mL 1.2 mL

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参考文献 for LNT 1

参考文献是支持产品生物活性的出版物。

Exell et al (2016) Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat.Chem.Bio. 12 815 PMID: 27526030

Ward et al (2017) Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One 12 e0179278 PMID: 28628639

If you know of a relevant reference for LNT 1, please let us know.

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关键词: LNT 1, LNT 1 supplier, LNT1, structure-specific, nuclease, human, flap, endonuclease-1, hFEN1, potent, inhibitors, inhibits, DNA, damage, response, Other, Hydrolases, DNA,, RNA, and, Protein, Synthesis, 6510, Tocris Bioscience

1 篇 LNT 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 LNT 1 的部分引用包括：

Mai et al (2021) NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells. NAR Cancer 3 zcab044 PMID: 34806016

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