Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewLoperamide hydrochloride
说明： Peripherally acting μ agonist; Ca2+ channel blocker
化学名： 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Loperamide hydrochloride
Loperamide hydrochloride is a high affinity μ-opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for μ-, δ- and κ-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations it reduces Ca2+ flux through NMDA receptor operated channels. Inhbits replication of MERS-CoV and SARS-CoV in vitro.
技术数据 for Loperamide hydrochloride
| 分子量 | 513.51 |
| 公式 | C29H33ClN2O2.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 34552-83-5 |
| PubChem ID | 71420 |
| InChI Key | PGYPOBZJRVSMDS-UHFFFAOYSA-N |
| Smiles | Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)C1=CC=C(Cl)C=C1)(C1=CC=CC=C1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Loperamide hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 10.27 | 20 | |
| DMSO | 10.27 | 20 |
制备储备液 for Loperamide hydrochloride
以下数据基于产品分子量 513.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.74 mL | 48.68 mL | 97.37 mL |
| 1 mM | 1.95 mL | 9.74 mL | 19.47 mL |
| 2 mM | 0.97 mL | 4.87 mL | 9.74 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.95 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Loperamide hydrochloride
参考文献 for Loperamide hydrochloride
参考文献是支持产品生物活性的出版物。
Awouters et al (1983) Pharmacology of antidiarrheal drugs. Annu.Rev.Pharmacol.Toxicol. 23 279 PMID: 6307123
Church et al (1994) Loperamide blocks high-voltage activated calcium channels and N-MthD.-aspartate -evoked responses in rat and mouse cultured hippocampal pyramidal neurons. Mol.Pharmacol. 45 747 PMID: 8183255
Daly et al (1995) Maitotoxin-elicited calcium influx in cultured cells - effect of calcium channel block. Biochem.Pharmacol. 50 1187 PMID: 7488233
Dehaven-Hudkins et al (1999) Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J.Pharmacol.Exp.Ther. 289 494 PMID: 10087042
de Wilde et al (2014) Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East Respiratory Syndrome coronavirus replication in cell culture. Antimicrob.Agents.Chemother. 58 4875
If you know of a relevant reference for Loperamide hydrochloride, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: Loperamide hydrochloride, Loperamide hydrochloride supplier, Ca2+, channel, blockers, HVA, L/N-type, NMDA, antagonists, reduces, flux, Peripherally, peripheral, μ-opioid, mu-opioid, agonists, Calcium, CaV, Channels, L-Type, N-Type, voltage-gated, voltage-dependent, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, MOP, OP3, Mu, Opioid, Cav1.x, Cav2.x, COVID-19, Coronavirus, 0840, Tocris Bioscience
1 篇 Loperamide hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Loperamide hydrochloride 的部分引用包括：
Sałaga et al (2015) Calea zacatechichi dichloromethane extract exhibits antidiarrheal and antinociceptive effects in mouse models mimicking irritable bowel syndrome. J Pharmacol Exp Ther 388 1069 PMID: 26068703
您是否知道使用了 Tocris Loperamide hydrochloride 的优秀论文？ 请告知我们.
Loperamide hydrochloride 的评论
目前没有该产品的评论。 Be the first to review Loperamide hydrochloride and earn rewards!
Have you used Loperamide hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.