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LP 922056

Cat. No. 6691 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Notum inhibitor; activates Wnt signaling
化学名： 2-[(6-Chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)thio]acetic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LP 922056

LP 922056 is a notum pectinacetylesterase inhibitor. LP 922056 activates wnt signaling in vitro (EC50 values are 21 nM in human and 55 nM in mouse cell-based assay). It increases cortical bone thickness in mouse model of bone growth. LP 922056 also inhibits growth of Apc-mutant cell lines and proliferation of intestinal adenomas in vivo.

化合物库 for LP 922056

LP 922056 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for LP 922056

分子量 300.78
公式 C11H9ClN2O2S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1365060-22-5
PubChem ID 56932967
InChI Key LJYRIWUQISYYHA-UHFFFAOYSA-N
Smiles OC(CSC1=C2SC(Cl)=C(C2=NC=N1)C3CC3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LP 922056

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.08 100

制备储备液 for LP 922056

以下数据基于产品分子量 300.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.32 mL 16.62 mL 33.25 mL
5 mM 0.66 mL 3.32 mL 6.65 mL
10 mM 0.33 mL 1.66 mL 3.32 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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产品说明书 for LP 922056

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for LP 922056

参考文献是支持产品生物活性的出版物。

Tarver et al (2016) Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg.Med.Chem.Lett 26 1525 PMID: 26897593

Brommage et al (2019) NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 7 PMID: 30622831

Flanagan et al (2021) NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature 594 430 PMID: 34079124

If you know of a relevant reference for LP 922056, please let us know.

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关键词: LP 922056, LP 922056 supplier, LP922056, notum, inhibitors, inhibits, wnt, signaling, activators, activates, O-palmitoleoyl-L-serine, hydrolase, pectinacetylesterase, osteoprorosis, NOTUMi, Other, Wnt, Signaling, Hydrolases, 6691, Tocris Bioscience

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