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Submit ReviewLUF 5834
说明： Potent adenosine A2A and A2B receptor partial agonist
化学名： 2-Amino-4-(4-hydroxyphenyl)-6-[(1H-imidazol-2-ylmethyl)thio]-3,5-pyridinecarbonitrile
纯度： ≥98% (HPLC)
生物活性 for LUF 5834
LUF 5834 is a potent A2A and A2B adenosine receptor partial agonist (Ki = 2.6 nM and EC50 = 12 nM respectively). Also exhibits selectivity for A1 over A3 (Ki values are 2.6 and 538 nM respectively).
化合物库 for LUF 5834
LUF 5834 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for LUF 5834
| 分子量 | 348.38 |
| 公式 | C17H12N6OS |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 333962-91-7 |
| PubChem ID | 1150683 |
| InChI Key | WLBUICQBNZXIDJ-UHFFFAOYSA-N |
| Smiles | NC1=NC(SCC3=NC=CN3)=C(C#N)C(C2=CC=C(O)C=C2)=C1C#N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LUF 5834
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 34.84 | 100 |
制备储备液 for LUF 5834
以下数据基于产品分子量 348.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.35 mL | 28.7 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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产品说明书 for LUF 5834
参考文献 for LUF 5834
参考文献是支持产品生物活性的出版物。
Beukers et al (2004) New, non-adenosine, high potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine J.Med.Chem 47 3707 PMID: 15239649
Lane et al (2012) A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A2a receptor Mol.Pharmacol. 81 475 PMID: 22188926
If you know of a relevant reference for LUF 5834, please let us know.
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关键词: LUF 5834, LUF 5834 supplier, LUF5834, potent, A2A, A2B, adenosine, receptors, agonists, Adenosine, Receptors, 4603, Tocris Bioscience
2 篇 LUF 5834 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LUF 5834 的部分引用包括：
Kurt et al (2021) A2A Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch. Structure 29 170-176.e3 PMID: 33238145
Gemma et al (2020) Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor. Comput Struct Biotechnol J 18 2723-2732 PMID: 33101610
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