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Submit ReviewLuteolin
说明： Anti-inflammatory, antioxidant and free radical scavenger
别名： 3',4',5,7-Tetrahydroxyflavone
化学名： 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
生物活性 for Luteolin
Luteolin is an anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α -induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo. Inhibits influenza virus replication in vitro by preventing viral entry. Molecular docking studies also indicate binding to SARS-CoV-2 main protease (Mpro or 3CLpro).
技术数据 for Luteolin
| 分子量 | 286.24 |
| 公式 | C15H10O6 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 491-70-3 |
| PubChem ID | 5280445 |
| InChI Key | IQPNAANSBPBGFQ-UHFFFAOYSA-N |
| Smiles | O=C(C=C(C3=CC(O)=C(O)C=C3)O2)C1=C2C=C(O)C=C1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Luteolin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. NaOH | 1.43 | 5 | |
| DMSO | 14.31 | 50 |
制备储备液 for Luteolin
以下数据基于产品分子量 286.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.99 mL | 34.94 mL | 69.87 mL |
| 2.5 mM | 1.4 mL | 6.99 mL | 13.97 mL |
| 5 mM | 0.7 mL | 3.49 mL | 6.99 mL |
| 25 mM | 0.14 mL | 0.7 mL | 1.4 mL |
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产品说明书 for Luteolin
参考文献 for Luteolin
参考文献是支持产品生物活性的出版物。
Ju et al (2007) A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells. Mol.Pharmacol. 71 1381 PMID: 17296806
Chen et al (2007) Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage. Life Sci. 81 1602 PMID: 17977562
Kim et al (2007) Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. Ann.N.Y.Acad.Sci. 1090 597 PMID: 17410645
Kim et al (2011) Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/ threonine kinase, inhibits tumor necrosis factor-α-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J.Pharm.Exp.Ther. 338 1013 PMID: 21705614
Yan et al (2019) Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression. J.Nat.Med. 73 487 PMID: 30758716
Yu et al (2020) Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking. Int.J.Antimicrob.Agents 56 106012 PMID: 32389723
If you know of a relevant reference for Luteolin, please let us know.
关键词: Luteolin, Luteolin supplier, Anti-inflammatory, antioxidant, free, radical, scavengers, NF-kB, NF-kappaB, NF-κB, inhibitors, inhibits, blocks, activation, antivirals, influenza, virus, COVID-19, SARS-CoV-2, main, protease, 3CLpro, 3',4',5,7-Tetrahydroxyflavone, Antioxidants, NF-kB/IkB, 2874, Tocris Bioscience
2 篇 Luteolin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Luteolin 的部分引用包括：
Cook et al (2017) Luteolin inhibits lung metastasis, cell migration, and viability of triple-negative breast cancer cells. Breast Cancer (Dove Med Press) 9 9 PMID: 28096694
Cook et al (2015) Luteolin inhibits progestin-dependent angiogenesis, stem cell-like characteristics, and growth of human breast cancer xenografts. Springerplus 4 444 PMID: 26312209
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