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Luzindole

Cat. No. 0877 16 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Competitive melatonin MT1/MT2 antagonist
化学名： N-Acetyl-2-benzyltryptamine
纯度： ≥98% (HPLC)
说明书
引用文献 (16)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Luzindole

Luzindole is a melatonin antagonist.

技术数据 for Luzindole

分子量 292.38
公式 C19H20N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 117946-91-5
PubChem ID 122162
InChI Key WVVXBPKOIZGVNS-UHFFFAOYSA-N
Smiles CC(=O)NCCC1=C(CC2=CC=CC=C2)NC2=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Luzindole

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.24 100
ethanol 29.24 100

制备储备液 for Luzindole

以下数据基于产品分子量 292.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.1 mL 34.2 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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产品说明书 for Luzindole

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Luzindole

参考文献是支持产品生物活性的出版物。

Dubocovich (1988) Luzindole (N-0774): a novel melatonin receptor antagonist. J.Pharmacol.Exp.Ther. 246 902 PMID: 2843633

Dubocovich et al (1990) Anti-depressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in mouse behavioural despair test. Eur.J.Pharmacol. 182 313 PMID: 2168835

Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083

If you know of a relevant reference for Luzindole, please let us know.

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关键词: Luzindole, Luzindole supplier, Competitive, melatonin, MT1, MT2, antagonists, Receptors, Melatonin, (MT), 0877, Tocris Bioscience

16 篇 Luzindole 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Luzindole 的部分引用包括：

Letra-Vilela et al (2016) Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin Molecular and Cellular Endocrinology 434 238 PMID: 27402602

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Neuroinflammation 336 127 PMID: 20959363

Muxel et al (2013) NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. Endocrinology 7 e52010 PMID: 23284853

Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179 PMID: 21091649

Legros et al (2014) Melatonin MT1 and MT2 receptors display different molecular pharmacologies only in the G-protein coupled state. Br J Pharmacol 171 186 PMID: 24117008

Nishiyama and Hirai (2014) The melatonin agonist rame. induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells. PLoS One 9 e102073 PMID: 25013953

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. J Clin Invest 20 1298 PMID: 24574803

Hou et al (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci 11 98 PMID: 28473754

Cecon et al (2015) Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway. FASEB J 29 2566 PMID: 25757565

Mickle et al (2010) Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process. Pain 149 555 PMID: 20413219

Baba et al (2013) Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. Sci Signal 6 ra89 PMID: 24106342

Faria et al (2013) Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats. Am J Physiol Endocrinol Metab 305 E230 PMID: 23695212

Silva et al (2007) Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro. Br J Pharmacol 151 195 PMID: 17375079

Roy et al (2001) Cyclical regulation of GnRH gene expression in GT1-7 GnRH-Secr.g neurons by melatonin. World J Gastroenterol 142 4711 PMID: 11606436

Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Pharmacol Exp Ther 108 625 PMID: 11518737

Savinainen et al (2005) Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. Br J Pharmacol 145 636 PMID: 15852035

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Luzindole 的评论

平均评分: 5 (Based on 1 Review.)

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Good MT1/MT2 agoinst.
By Kishor Pant on 11/30/2022
分析类型： In Vitro
种属： Human
细胞系/组织： HepG2, and Huh,

It is a good MT1/MT2 agonist. Can activate cAMP and its downstream targets. Used at 10 uM concentration

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