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Submit ReviewLY 225910
说明： Potent CCK2 antagonist
化学名： 2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-4-(3H)-quinazoline
生物活性 for LY 225910
LY 225910 is a potent CCK2 receptor antagonist (IC50 = 9.3 nM for inhibition of 125I-labeled CCK-8 sulfate binding at mouse brain membranes).
许可信息
Sold with the permission of Eli Lilly and Company.
技术数据 for LY 225910
| 分子量 | 502.41 |
| 公式 | C27H24BrN3O2 |
| 储存 | Desiccate at -20°C |
| CAS Number | 133040-77-4 |
| PubChem ID | 4355450 |
| InChI Key | KUECXUACQOYKNB-UHFFFAOYSA-N |
| Smiles | CC(C)OC1=CC=CC(=C1)N1C(CCC2=CNC3=CC=C(Br)C=C23)=NC2=C(C=CC=C2)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LY 225910
参考文献 for LY 225910
参考文献是支持产品生物活性的出版物。
Suman-Chauhan et al (1996) The influence of guanyl nucleotide on agonist and antagonist affinity at guinea-pig CCK-B / gastrin receptors: binding studies using [3H]PD140376. Regul.Pept. 65 37 PMID: 8876034
Yu et al (1991) Quinazolinone cholecystokinin receptor ligands. J.Med.Chem. 34 1505 PMID: 2016728
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关键词: LY 225910, LY 225910 supplier, Potent, CCK2, antagonists, Cholecystokinin2, Receptors, LY225910, Receptor, 1018, Tocris Bioscience
3 篇 LY 225910 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LY 225910 的部分引用包括：
Gallopin et al (2006) Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. Neuropsychopharmacology 16 1440 PMID: 16339088
Seillier et al (2013) Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB1 receptors: implications for schizophrenia. Neuropharmacology 38 1816 PMID: 23563893
Karson et al (2008) Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others. J Card Fail 54 117 PMID: 17689570
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