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Submit ReviewLY 233053
说明： Competitive NMDA antagonist
化学名： (2R*,4S*)-4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylic acid
纯度： ≥99% (HPLC)
生物活性 for LY 233053
LY 233053 is a competitive NMDA receptor antagonist (IC50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 μM. Inhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats.
许可信息
Sold with the permission of Eli Lilly and Company
技术数据 for LY 233053
| 分子量 | 211.22 |
| 公式 | C8H13N5O2 |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 125546-04-5 |
| PubChem ID | 90479799 |
| InChI Key | RTVQJOXSBRCZBN-JUKSSJACSA-N |
| Smiles | O=[C@@]([C@@H]1C[C@H](CC2=NN=NN2)CCN1)O.O=C([C@H]3C[C@@H](CC4=NN=NN4)CCN3)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LY 233053
参考文献 for LY 233053
参考文献是支持产品生物活性的出版物。
Schoepp et al (1990) Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-MthD.-aspartic acid antagonist with a short duration of action. J.Pharmacol.Exp.Ther. 255 1301 PMID: 2148188
Madden et al (1992) Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia. J.Neurosurg. 76 106 PMID: 1727148
Madden et al (1993) Delayed therapy of experimental ischemia with competitive N-MthD.-aspartate antagonists in rabbits. Stroke 24 1068 PMID: 8322381
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关键词: LY 233053, LY 233053 supplier, Competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, LY233053, 1521, Tocris Bioscience
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