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说明： High affinity and selective RARγ antagonist
化学名： 4-[5-[3,5-Bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]benzoic acid
纯度： ≥98% (HPLC)
生物活性 for LY 2955303
LY 2955303 is a high affinity and selective RARγ antagonist (Ki values are 1.1 nM, >1.7 μM and >2.9 μM for RARγ, RARα and RARβ respectively). Displays analgesic efficacy in a mouse model of osteoarthritis-like joint pain.
化合物库 for LY 2955303
LY 2955303 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for LY 2955303
| 分子量 | 578.74 |
| 公式 | C36H42N4O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1433497-19-8 |
| PubChem ID | 71552369 |
| InChI Key | YVXYHNKIOFSFMZ-UHFFFAOYSA-N |
| Smiles | CN1CCN(C(C2=CC=C(N3N=C(C4=CC=C(C(O)=O)C=C4)C=C3C5=CC(C(C)(C)C)=CC(C(C)(C)C)=C5)C=C2)=O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LY 2955303
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 11.57 | 20 |
制备储备液 for LY 2955303
以下数据基于产品分子量 578.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.64 mL | 43.2 mL | 86.39 mL |
| 1 mM | 1.73 mL | 8.64 mL | 17.28 mL |
| 2 mM | 0.86 mL | 4.32 mL | 8.64 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.73 mL |
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产品说明书 for LY 2955303
参考文献 for LY 2955303
参考文献是支持产品生物活性的出版物。
Hughes et al (2016) Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg.Med.Chem.Letts. 26 3274 PMID: 27261179
If you know of a relevant reference for LY 2955303, please let us know.
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关键词: LY 2955303, LY 2955303 supplier, LY2955303, selective, retinoic, acid, receptor, gamma, RARg, antagonists, antagonism, osteoarthritis, high, affinity, Retinoic, Acid, Receptors, 5984, Tocris Bioscience
1 篇 LY 2955303 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LY 2955303 的部分引用包括：
Takashi et al (2023) Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase. Cancer Cell Int 23 94 PMID: 37198667
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.