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Submit ReviewLY 334370 hydrochloride
说明： Selective 5-HT1F agonist
化学名： 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for LY 334370 hydrochloride
LY 334370 hydrochloride is a selective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50) and 3250 nM for 5-HT1F, 5-HT1A, 5-HT4, 5-HT1E, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT2A, 5-HT7, 5-HT6 and 5-HT2C receptors respectively). Displays antimigraine effects.
许可信息
Sold under license from Eli Lilly and company
技术数据 for LY 334370 hydrochloride
| 分子量 | 387.88 |
| 公式 | C21H22FN3O.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 199673-74-0 |
| PubChem ID | 19710026 |
| InChI Key | DGPDGAPZTPSHBL-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=C(F)C=C4)NC1=CC=C(NC=C2C3CCN(C)CC3)C2=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LY 334370 hydrochloride
参考文献 for LY 334370 hydrochloride
参考文献是支持产品生物活性的出版物。
Dupuis et al (1998) G-protein activationat 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines. Br.J.Pharmacol. 124 283 PMID: 9641544
Shepheard et al (1999) Possible antimigraine mechanisms of action of the 5-HT1F receptor agonist LY334370. Cephalalgia 19 851 PMID: 10668103
Wainscott et al (2005) [H3]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties. Naunyn-Schmied.Arch.Pharmacol. 371 169
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关键词: LY 334370 hydrochloride, LY 334370 hydrochloride supplier, Selective, 5-HT1F, agonists, Serotonin, Receptors, LY334370, hydrochloride, 3079, Tocris Bioscience
1 篇 LY 334370 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LY 334370 hydrochloride 的部分引用包括：
Garrett et al (2014) Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury. J Pharmacol Exp Ther 350 257 PMID: 24849926
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.