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说明： Phenylethanolamine-N-methyltransferase inhibitor
化学名： 2,3-Dichloro-α-methylbenzylamine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for LY 78335
LY 78335 is a high affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.
技术数据 for LY 78335
| 分子量 | 226.53 |
| 公式 | C8H9Cl2N.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 39959-66-5 |
| PubChem ID | 11957540 |
| InChI Key | FQTXPVLCCDQRHY-UHFFFAOYSA-N |
| Smiles | NC(C)C1=C(Cl)C(Cl)=CC=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LY 78335
参考文献 for LY 78335
参考文献是支持产品生物活性的出版物。
Fuller et al (1973) Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine. J.Med.Chem. 16 106 PMID: 4683104
Terry et al (1982) Regulation of episodic GH secretion by the central epinephrine system. J.Clin.Invest. 69 104 PMID: 7054231
Grunewald et al (1988) Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. J.Med.Chem. 31 824 PMID: 3351861
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关键词: LY 78335, LY 78335 supplier, LY78335, phenylethanolamine-N-methyltransferase, PNMT, high, affinity, inhibitors, inhibits, methyltransferases, Other, Transferases, 4060, Tocris Bioscience
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