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Submit ReviewLys-CoA
说明： Selective p300 inhibitor
化学名： S-[2-[[(5S)-5-(Acetylamino)-6-amino-6-oxohexyl]amino]-2-oxoethyl]coenzyme A trifluoroacetate
纯度： ≥95% (HPLC)
生物活性 for Lys-CoA
Lys-CoA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo.
技术数据 for Lys-CoA
| 分子量 | 1108.82 |
| 公式 | C31H53N10O19P3S.C2HF3O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| Smiles | O[C@H]([C@@H]1OP(O)(O)=O)[C@@H](O[C@@H]1COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)N2C3=NC=NC(N)=C3N=C2.OC(C(F)(F)F)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Lys-CoA
参考文献 for Lys-CoA
参考文献是支持产品生物活性的出版物。
Lau et al (2000) HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol.Cell. 5 589 PMID: 10882143
Liu et al (2008) The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 451 846 PMID: 18273021
Burns et al (2005) Iso-coenzyme A. J.Biol.Chem. 280 16550 PMID: 15708855
Cebrat et al (2003) Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg.Med.Chem. 11 3307 PMID: 12837541
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关键词: Lys-CoA, Lys-CoA supplier, Lys-CoA, p300, histone, acetyltransferase, inhibitors, inhibits, HAT, selective, active, in, vivo, Histone, Acetyltransferases, Post-translational, Modifications, 5103, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.