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Submit Review[Lys5,MeLeu9,Nle10]-NKA(4-10)
说明： Selective NK2 agonist
生物活性 for [Lys5,MeLeu9,Nle10]-NKA(4-10)
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
技术数据 for [Lys5,MeLeu9,Nle10]-NKA(4-10)
| 分子量 | 804 |
| 公式 | C39H65N9O9 |
| 序列 |
DKFVGLX (Modifications: Leu-6 = Leu(N-methyl), X = Nle & C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 137565-28-7 |
| PubChem ID | 10417908 |
| InChI Key | FIBMQAYBIOYAKI-HLYNNXGTSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for [Lys5,MeLeu9,Nle10]-NKA(4-10)
参考文献 for [Lys5,MeLeu9,Nle10]-NKA(4-10)
参考文献是支持产品生物活性的出版物。
Chassaing et al (1991) Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay). Neuropeptides 19 91 PMID: 1658676
Matuszek et al (1998) An investigation of tachykinin NK2 receptor subtypes in the rat. Eur.J.Pharmacol. 352 103 PMID: 9718274
Burcher et al (2008) Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomet. and in diverticular disease and ulcerative colitis. J.Pharmacol.Exp.Ther. 324 170 PMID: 17959748
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关键词: [Lys5,MeLeu9,Nle10]-NKA(4-10), [Lys5,MeLeu9,Nle10]-NKA(4-10) supplier, Selective, NK2, agonists, Tachykinin, Receptors, Neurokinin, Receptor, 3228, Tocris Bioscience
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