主页 / 药理学 / GPCRs / 7-TM Receptors / Smoothened Receptors / Smoothened Receptor Antagonists / M 25

M 25

Cat. No. 4917 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4917 has been discontinued.

View all Smoothened Receptors products.
说明： Potent Smoothened (Smo) receptor antagonist
化学名： N-[[1-(2-Methoxyphenyl)-1H-indazol-5-yl]methyl]-2-propylpentanamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for M 25

M 25 is a potent Smoothened (Smo) receptor antagonist (IC50 = 5 nM). Inhibits the Hedgehog signaling pathway. Inhibits Shh induced Gli luciferase reporter activity in Shh-light 2 cells (IC50 = 5 nM). Antagonizes GSA-10 and SAG-mediated differentiation of the C3H10T1/2 cell line (IC50 values are 69 and 115 nM, respectively).

技术数据 for M 25

分子量 379.5
公式 C23H29N3O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
PubChem ID 44250034
InChI Key WATNXVHKRRTUFK-UHFFFAOYSA-N
Smiles O=C(C(CCC)CCC)NCC1=CC=C(N(C3=CC=CC=C3OC)N=C2)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for M 25

参考文献是支持产品生物活性的出版物。

Dessole et al (2009) Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway. Bioorg.Med.Chem.Lett. 19 4191 PMID: 19540115

Gorojankina et al (2013) Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol.Pharmacol. 83 1020 PMID: 23448715

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Smoothened Receptor Antagonists

关键词: M 25, M 25 supplier, M25, Smoothened, SMO, antagonists, inhibitors, inhibits, Hedgehog, signaling, pathway, SAG, Receptors, Signaling, 4917, Tocris Bioscience

篇 M 25 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 M 25 的引用文献。

M 25 的评论

目前没有该产品的评论。 Be the first to review M 25 and earn rewards!

Have you used M 25?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products