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Submit ReviewM 30 dihydrochloride
说明： Potent and non-selective MAO inhibitor; also an iron chelator and antioxidant
化学名： N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for M 30 dihydrochloride
M 30 dihydrochloride is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA (Cat. No. 2547) induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.
技术数据 for M 30 dihydrochloride
| 分子量 | 299.2 |
| 公式 | C14H14N2O.2HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 64821-19-8 |
| PubChem ID | 71311622 |
| InChI Key | XJNICPXVRPOSSO-UHFFFAOYSA-N |
| Smiles | CN(CC#C)CC1=C2C(N=CC=C2)=C(O)C=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for M 30 dihydrochloride
参考文献 for M 30 dihydrochloride
参考文献是支持产品生物活性的出版物。
Zheng et al (2005) Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons. Biochem.Pharmacol. 70 1642 PMID: 16226724
Zheng (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition. J.Neurochem. 95 68 PMID: 16181413
Gal et al (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal DA depletion. J.Neurochem. 95 79 PMID: 16181414
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关键词: M 30 dihydrochloride, M 30 dihydrochloride supplier, M30, dihydrochloride, MAO, monoamine, oxidase, MAOA, MAOB, inhibitors, inhibits, non-selective, potent, antioxidant, iron, chelator, Monoamine, Oxidase, Antioxidants, Biochemicals, and, Molecular, Biology, 6067, Tocris Bioscience
1 篇 M 30 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 M 30 dihydrochloride 的部分引用包括：
Matthias et al (2022) Endogenously produced catecholamines improve the regulatory function of TLR9-activated B cells. PLoS Biol 20 e3001513 PMID: 35073310
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.