m-Chlorophenylbiguanide hydrochloride

Cat. No. 0440 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective 5-HT₃ agonist

化学名： 1-(3-Chlorophenyl)biguanide hydrochloride

纯度： ≥98% (HPLC)

引用文献 (4)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for m-Chlorophenylbiguanide hydrochloride

m-Chlorophenylbiguanide hydrochloride is a prototypical potent and selective 5-HT₃ receptor agonist.

技术数据 for m-Chlorophenylbiguanide hydrochloride

分子量	248.11
公式	C₈H₁₀ClN₅.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	2113-05-5
PubChem ID	2730228
InChI Key	FOWAIJYHRWFTHR-UHFFFAOYSA-N
Smiles	Cl.NC(=N)NC(=N)NC1=CC(Cl)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for m-Chlorophenylbiguanide hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	24.81	100

制备储备液 for m-Chlorophenylbiguanide hydrochloride

以下数据基于产品分子量 248.11。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.03 mL	20.15 mL	40.3 mL
5 mM	0.81 mL	4.03 mL	8.06 mL
10 mM	0.4 mL	2.02 mL	4.03 mL
50 mM	0.08 mL	0.4 mL	0.81 mL

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产品说明书 for m-Chlorophenylbiguanide hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for m-Chlorophenylbiguanide hydrochloride

参考文献是支持产品生物活性的出版物。

Boess et al (1992) 5HT₃ receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide. Neuropharmacology 31 561 PMID: 1407396

Kilpatrick et al (1990) 1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT₃ receptor agonist. Eur.J.Pharmacol. 182 193 PMID: 2144822

Niemeyer and Lummis (1998) Different efficacy of specific agonists at 5-HT₃ receptor splice variants: the role of the extra six amino acid segment. Br.J.Pharmacol. 123 661 PMID: 9517385

Sepulveda et al (1991) The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT₃ receptors in N1E-115 neuroblastoma cells. Br.J.Pharmacol. 104 536 PMID: 1797317

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关键词: m-Chlorophenylbiguanide hydrochloride, m-Chlorophenylbiguanide hydrochloride supplier, Potent, selective, specific, 5-HT3, agonists, Serotonin, Receptors, 0440, Tocris Bioscience

4 篇 m-Chlorophenylbiguanide hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 m-Chlorophenylbiguanide hydrochloride 的部分引用包括：

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643

Dale et al (2014) Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol 28 891 PMID: 25122043

Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. PLoS One 29 13909 PMID: 19890001

Gill et al (2008) Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 295 G700 PMID: 18669621

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