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M4K2163 dihydrochloride

Cat. No. 7754 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective ALK2 inhibitor
化学名： 1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (4)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for M4K2163 dihydrochloride

M4K2163 is a potent and selective activin receptor-like kinase 2 (ALK2) inhibitor (IC50 values are 19 nM in vivo and 98 nM in vitro). Orally bioavailable and brain penetrant.

技术数据 for M4K2163 dihydrochloride

分子量 480.41
公式 C24H26FN3O2.2HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2863635-04-3
InChI Key HMNLQIQCOZETBK-UHFFFAOYSA-N
Smiles FC1=C(OC)C=C(C2=CN=CC(C3=CC=C(N4CCNCC4)C=C3)=C2C)C=C1OC.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for M4K2163 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 48.04 100
DMSO 48.04 100

制备储备液 for M4K2163 dihydrochloride

以下数据基于产品分子量 480.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.41 mL 20.82 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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产品说明书 for M4K2163 dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for M4K2163 dihydrochloride

参考文献是支持产品生物活性的出版物。

Smil et al (2020) Leveraging an open science drug discovery model to develop CNS-penetrant ALK2 inhibitors for the treatment of diffuse intrinsic pontine glioma. J.Med.Chem. 63 10061 PMID: 32787083

Rooney and Jones (2021) Recent advances in ALK2 inhibitors. ACS Omega 6 20729 PMID: 34423181

If you know of a relevant reference for M4K2163 dihydrochloride, please let us know.

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关键词: M4K2163 dihydrochloride, M4K2163 dihydrochloride supplier, ALK2, activin, A, kinase, 2, inhibitors, potent, selective, bioavailable, brain, penetrant, BMP, and, Other, Activin, Receptors, 7754, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for M4K2163 dihydrochloride

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