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说明： Selective GAL1 agonist
别名： Galanin(1-13)-Gln14-bradykinin(2-9)amide
纯度： ≥95% (HPLC)
生物活性 for M617
M617 is a selective galanin GAL1 receptor agonist (Ki values are 0.23 and 5.71 nM for GAL1 and GAL2 receptors respectively). Enhances food consumption in rats following i.c.v. administration and reduces CAP-induced inflammatory pain.
技术数据 for M617
| 分子量 | 2361.68 |
| 公式 | C112H161N29O28 |
| 序列 |
GWTLNSAGYLLGPQPPGFSPFR (Modifications: Arg-22 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 860790-38-1 |
| PubChem ID | 16158157 |
| InChI Key | PAYBRARNTYCYOT-OTTBQUPZSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for M617
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for M617
参考文献 for M617
参考文献是支持产品生物活性的出版物。
Mazarati et al (2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 318 700 PMID: 16699066
Jimenez-Andrade et al (2006) Activation of peripheral galanin receptors: differential effects on nociception. Pharmacol.Biochem.Behav. 85 273 PMID: 16996122
Lundstrom et al (2005) A galanin receptor subtype 1 specific agonist. Int.J.Pept.Res.Ther. 11 17
If you know of a relevant reference for M617, please let us know.
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关键词: M617, M617 supplier, Selective, GAL1, GalR1, agonists, Receptors, Galanin, Galanin(1-13)-Gln14-bradykinin(2-9)amide, 2697, Tocris Bioscience
1 篇 M617 的引用文献
引用文献是使用了 Tocris 产品的出版物。 M617 的部分引用包括：
Li (2017) Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats. Sci Rep 7 15317 PMID: 29127424
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.