M8 B hydrochloride

Cat. No. 5324 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective TRPM8 channel blocker

化学名： N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride

纯度： ≥99% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for M8 B hydrochloride

M8 B hydrochloride is a potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC₅₀ values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC₅₀ > 20 μM). Reduces body temperature in vivo.

化合物库 for M8 B hydrochloride

M8 B hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for M8 B hydrochloride

分子量	432.96
公式	C₂₂H₂₄N₂O₃S.HCl
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	883976-12-3
PubChem ID	69316632
InChI Key	FMQJBHACRTZLME-UHFFFAOYSA-N
Smiles	COC1=C(OCC2=CC=CC=C2)C=CC(CN(CCN)C(C3=CC=CS3)=O)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for M8 B hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	4.33	10 超声处理
	DMSO	43.3	100

制备储备液 for M8 B hydrochloride

以下数据基于产品分子量 432.96。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.55 mL	23.1 mL
5 mM	0.46 mL	2.31 mL	4.62 mL
10 mM	0.23 mL	1.15 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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产品说明书 for M8 B hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for M8 B hydrochloride

参考文献是支持产品生物活性的出版物。

Almeida et al (2012) Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J.Neurosci. 32 2086 PMID: 22323721

If you know of a relevant reference for M8 B hydrochloride, please let us know.

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