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说明： Selective GAL2 antagonist
别名： Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide
纯度： ≥95% (HPLC)
生物活性 for M871
M871 is a selective galanin GAL2 receptor antagonist (Ki values are 13.1 and 420 nM for GAL2 and GAL1 receptors respectively). Blocks the pro-nociceptive effect of GAL2 receptor agonists.
技术数据 for M871
| 分子量 | 2287.64 |
| 公式 | C108H163N27O28 |
| 序列 |
WTLNSAGYLLGPEHPPPALALA (Modification: Ala-22 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 908844-75-7 |
| PubChem ID | 90477989 |
| InChI Key | BHKXASDHGWBINL-ZEHYZEGSSA-N |
| Smiles | [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for M871
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for M871
参考文献 for M871
参考文献是支持产品生物活性的出版物。
Jimenez-Andrade et al (2006) Activation of peripheral galanin receptors: differential effects on nociception. Pharmacol.Biochem.Behav. 85 273 PMID: 16996122
Sollenburg et al (2006) M871 - a novel peptide antagonist selectively recognizing the galanin receptor type 2. Int.J.Pept.Res.Ther. 12 115
If you know of a relevant reference for M871, please let us know.
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关键词: M871, M871 supplier, Selective, GAL2, GalR2, antagonists, Receptors, Galanin, Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide, 2698, Tocris Bioscience
6 篇 M871 的引用文献
引用文献是使用了 Tocris 产品的出版物。 M871 的部分引用包括：
Funck (2018) Dorsal hippocampal galanin modulates anxiety-like behaviours in rats. Brain Res 1688 75 PMID: 29499176
Fang (2018) Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats. Biochem Pharmacol 156 241 PMID: 30170096
Scanlon et al (2015) Galanin modulates the neural niche to favour perineural invasion in head and neck cancer. Int J Neuropsychopharmacol 6 6885 PMID: 25917569
Millón et al (2015) A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats. Immun Inflamm Dis 18 PMID: 25522404
Zhang (2017) Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulatecortex of normal rats and rats with mononeuropathy Sci Rep 7 45930 PMID: 28378856
Millòn et al (2014) A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats. Int.J.Neuropsychopharmacol. 18 PMID: 25522404
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.