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说明： Potent, irreversible FAAH inhibitor
化学名： (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyl-methyl ester phosphonofluoridic acid
生物活性 for MAFP
Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC50 = 2.5 nM). Also binds irreversibly to CB1 receptors (IC50 = 20 nM).
技术数据 for MAFP
| 分子量 | 370.49 |
| 公式 | C21H36FO2P |
| 储存 | Desiccate at -80°C |
| CAS Number | 188404-10-6 |
| Smiles | CCCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCP(F)(OC)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MAFP
参考文献 for MAFP
参考文献是支持产品生物活性的出版物。
De Petrocellis et al (1997) Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase. Biochem.Biophys.Res.Commun. 231 82 PMID: 9070224
Deutsch et al (1997) Methyl arachidonyl fluorophosphate: a potent irreversible inhibitor of anandamide amidase. Biochem.Pharmacol. 53 255 PMID: 9065728
Martin et al (2000) Cannabinoid properties of methylfluorophosphonate analogs. J.Pharmacol.Exp.Ther. 294 1209 PMID: 10945879
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关键词: MAFP, MAFP supplier, Potent, irreversible, FAAH, inhibitors, inhibits, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, Cannabinoids, Receptors, Other, Hydrolase, (FAAH), 1421, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.