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Submit ReviewMargatoxin
Discontinued Product
3563 has been discontinued.
View all Voltage-gated Potassium (K<sub>V</sub>) Channels products.
说明： Potent KV1.3 channel blocker
别名： MgTX
纯度： ≥95% (HPLC)
生物活性 for Margatoxin
Margatoxin is a potent KV1.3 channel blocker (IC50 = 36 pM). Displays no effect at calcium-activated channels. Reduces VEGF-induced transmembrane calcium influxes and nitric oxide production in human endothelial cells.
技术数据 for Margatoxin
| 分子量 | 4178.96 |
| 公式 | C178H286N52O50S7 |
| 序列 |
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH (Modifications: Disulfide bridges: 7-29, 13-34, 17-36) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 145808-47-5 |
| PubChem ID | 121596045 |
| InChI Key | OVJBOPBBHWOWJI-FYNXUGHNSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CO)NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC2=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Margatoxin
参考文献 for Margatoxin
参考文献是支持产品生物活性的出版物。
Garcia-Calvo et al (1993) Purification, characterization, and biosynthesis of Margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels. J.Biol.Chem. 268 18866 PMID: 8360176
Erdogan et al (2005) Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells. J.Vasc.Res. 42 368 PMID: 16043967
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关键词: Margatoxin, Margatoxin supplier, Kv1.3, channel, blocker, voltage-gated, potassium, channels, MgTX, MTX, venoms, Voltage-Gated, Potassium, Channels, 3563, Tocris Bioscience
1 篇 Margatoxin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Margatoxin 的部分引用包括：
Frauke et al (2020) β1-Integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells. J Clin Invest 130 715-732 PMID: 31661467
Margatoxin 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Margatoxin?
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Great water soluble selective Kv channel blocker.
By
Anonymous on 10/15/2018
分析类型： In Vitro
种属： Human
Margatoxin was used in our lab to study SK channel opening and blocking effect. Margatoxin was used to compare with other selective SK channel blockers as they do not show significant SK blocking. The product performed excellent in sterile cell culture labs and would high recommend. The product is water soluble which is also a plus.
