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Submit ReviewMCH (human, mouse, rat)
说明： Potent endogenous MCH agonist
别名： Melanin-concentrating hormone (human,mouse,rat)
纯度： ≥95% (HPLC)
生物活性 for MCH (human, mouse, rat)
MCH (human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 and 0.1 nM at MCH1 and MCH2 receptors respectively). Increases food intake in vivo.
技术数据 for MCH (human, mouse, rat)
| 分子量 | 2386.84 |
| 公式 | C105H160N30O26S4 |
| 序列 |
DFDMLRCMLGRVYRPCWQV (Modification: Disulfide bridge: 7-16) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 128315-56-0 |
| PubChem ID | 24868207 |
| InChI Key | MWLPXSMFEPHETN-QRXCLJFASA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MCH (human, mouse, rat)
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for MCH (human, mouse, rat)
参考文献 for MCH (human, mouse, rat)
参考文献是支持产品生物活性的出版物。
Sailer et al (2001) Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc.Natl.Acad.Sci.USA 98 7564
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关键词: MCH (human, mouse, rat), MCH (human, mouse, rat) supplier, potent, endogenous, MCH, agonists, receptors, melanin-concentration, hormone, MCH1, MCH2, MCH2R, MCHR2, MCH1R, MCHR1, Melanin-concentrating, Melanin, concentrating, concentration, (human,, mouse,, rat), Hormone, Receptors, 3806, Tocris Bioscience
6 篇 MCH (human, mouse, rat) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MCH (human, mouse, rat) 的部分引用包括：
Hi-Joon et al (2019) Acupuncture Alleviates Levodopa-Induced Dyskinesia via Melanin-Concentrating Hormone in Pitx3-Deficient aphakia and 6-Hydroxydopamine-Lesioned Mice. Mol Neurobiol 56 2408-2423 PMID: 30030752
Jang (2018) Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice. Sci Rep 8 707 PMID: 29335480
Kim and Han (2016) Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors. Exp Neurobiol 25 307 PMID: 28035181
Kazumoto et al (2023) Loss of hypothalamic MCH decreases food intake in amyotrophic lateral sclerosis. Acta Neuropathol 145 773-791 PMID: 37058170
Hi-Joon et al (2020) Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in Rodents. Exp Neurobiol 29 453-469 PMID: 33372169
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
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