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Submit ReviewMCL 0020
说明： Selective MC4 receptor antagonist
生物活性 for MCL 0020
MCL 0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.
技术数据 for MCL 0020
| 分子量 | 609.73 |
| 公式 | C34H39N7O4 |
| 序列 |
XRX (Modifications: X-1 = Ac-D-2-Nal, X-3 = 2-Nal & C-terminal amide) |
| 储存 | Store at -20°C |
| CAS Number | 475498-26-1 |
| PubChem ID | 9938789 |
| InChI Key | FJFLYSMWSRRMRO-FRXPANAUSA-N |
| Smiles | CC(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MCL 0020
参考文献 for MCL 0020
参考文献是支持产品生物活性的出版物。
Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95 PMID: 12909200
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关键词: MCL 0020, MCL 0020 supplier, Selective, MC4R, receptor, antagonists, Receptors, Melanocortin, MCL0020, 3438, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.