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Submit ReviewMDA 19
说明： CB2 agonist
化学名： N'-[(3Z)-1-Hexyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide
纯度： ≥99% (HPLC)
生物活性 for MDA 19
MDA 19 is a CB2 receptor agonist. Displays 4-fold higher affinity for the human CB2 receptor than the human CB1 receptor (Ki values are 43.3 and 162.4 nM respectively); shows 70-fold affinity for the rat CB2 receptor over the rat CB1 receptor (Ki values are 16.3 and 1130 nM respectively). Attenuates tactile allodynia in a rat model; does not affect rat locomotor activity.
技术数据 for MDA 19
| 分子量 | 349.43 |
| 公式 | C21H23N3O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1048973-47-2 |
| PubChem ID | 25034599 |
| InChI Key | ZGQHMZCITJHYOW-QOCHGBHMSA-N |
| Smiles | O=C(C3=CC=CC=C3)N\N=C(C1=CC=CC=C1N2CCCCCC)/C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MDA 19
参考文献 for MDA 19
参考文献是支持产品生物活性的出版物。
Diaz et al (2008) Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain. J.Med.Chem. 51 4932 PMID: 18666769
Xu et al (2010) Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain. Anesth.Analg. 111 99 PMID: 20522703
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关键词: MDA 19, MDA 19 supplier, MDA19, cb2, cannabinoid, agonists, CB2, Receptors, 4205, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.