Mdivi 1

Cat. No. 3982 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

化学名： 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone

纯度： ≥98% (HPLC)

引用文献 (7)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Mdivi 1

Mdivi 1 is a selective inhibitor of dynamin GTPase (IC₅₀ = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis. In a cell model, Mdivi 1 protects against mutant huntington-induced damage and mitochondrial dysfunction. Mdivi 1 also inhibits autophagy and protects neurons from excitotoxicity.

技术数据 for Mdivi 1

分子量	353.22
公式	C₁₅H₁₀C_l2N₂O₂S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	338967-87-6
PubChem ID	3825829
InChI Key	NZJKEVWTYMOYOR-UHFFFAOYSA-N
Smiles	O=C2N(C3=C(Cl)C=C(Cl)C(OC)=C3)C(S)=NC1=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mdivi 1

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	35.32	100

制备储备液 for Mdivi 1

以下数据基于产品分子量 353.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.16 mL	28.31 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.42 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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产品说明书 for Mdivi 1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Mdivi 1

参考文献是支持产品生物活性的出版物。

Tanaka and Youle (2008) A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol.Cell 29 409 PMID: 18313377

Lackner et al (2010) Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine. Chem.Biol. 17 57 PMID: 20142041

Cassidy-Stone et al (2008) Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Develop.Cell 14 193

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

Park et al (2011) A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest.Ophthalmol Vis.Sci. 52 2837 PMID: 21372007

Ruiz et al (2018) Mitochondrial division inhibitor 1 (mdivi-1) protects neurons against excitotoxicity through the modulation of mitochondrial function and intracellular Ca ²⁺ signaling. Front.Mol.Neurosci. PMID: 29386996

Manczak and Reddy (2015) Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease. Hum.Mol.Genet. 24 7308 PMID: 26464486

If you know of a relevant reference for Mdivi 1, please let us know.

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