MDL 28170

Name: MDL 28170
Brand: Tocris Bioscience
SKU: 1146

Cat. No. 1146 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1146 has been discontinued.

View all Calcium-Sensitive Proteases products.

说明： Potent, selective calpain and cathepsin B inhibitor

化学名： N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal

纯度： ≥95% (HPLC)

说明书

引用文献 (3)

生物活性技术数据说明书参考文献

生物活性 for MDL 28170

Potent, selective inhibitor of calpain and cathepsin B (K_i values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.

技术数据 for MDL 28170

分子量	382.45
公式	C₂₂H₂₆N₂O₄
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	88191-84-8
PubChem ID	11199915
InChI Key	NGBKFLTYGSREKK-ANYOKISRSA-N
Smiles	O=C(N[C@@H]([C@H](C)C)C(NC(CC2=CC=CC=C2)C([H])=O)=O)OCC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for MDL 28170

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MDL 28170

参考文献是支持产品生物活性的出版物。

Chen et al (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 769 188 PMID: 9374290

Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17 PMID: 9637399

Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150 PMID: 1877091

Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960 PMID: 17600513

按标靶查看相关产品

关键词: MDL 28170, MDL 28170 supplier, Potent, selective, calpain, cathepsin, B, inhibitors, inhibits, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, MDL28170, Calpains, Cathepsin, 1146, Tocris Bioscience