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Submit ReviewMDL 29,913 is a NK2 tachykinin receptor selective antagonist.
分子量 | 745 |
公式 | C40H56N8O6 |
序列 |
QWFGLL (Modifications: Leu-5 - Leu-6 = Leu-CH2N(CH3)-Leu, Cyclized) |
储存 | Desiccate at -20°C |
CAS Number | 135721-56-1 |
PubChem ID | 90479769 |
InChI Key | HTXNHRVBQSWFDI-QEQIFPIFSA-N |
Smiles | CC(C)C[C@@H]1NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC1C |
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参考文献是支持产品生物活性的出版物。
Black et al (1992) Tachykinin receptors in rabbit airways - characterization by functional, autoradiographic and binding studies. Br.J.Pharmacol. 107 429 PMID: 1384914
Maggi et al (1993) MEN 10,573 and MEN 10,612, novel cyclic pseudopeptides which are potent tachykinin NK-2 receptor antagonists. Regul.Pept. 47 151 PMID: 8234901
关键词: MDL 29,913, MDL 29,913 supplier, Selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, MDL29913, Receptor, 1194, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 MDL 29,913 的部分引用包括:
Wease and Davies (2005) Substance P selectively decreases paired pulse depression in the rat hippocampal slice. BMC Neurosci 6 66 PMID: 16305744
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.